Induction of Total Intravenous General Anesthesia Clinical Trial
Official title:
Comparison of Three Different Strategies to Prevent Propofol Induced Pain During Infusion
Propofol is a popular intravenous drug to induce anesthesia but it causes local pain with an incidence between 40 and 90%. Three different strategies to prevent propofol induced pain will be studied compared with placebo. Pain will be scored with a four-point scale.
| Status | Active, not recruiting |
| Enrollment | 200 |
| Est. completion date | |
| Est. primary completion date | |
| Accepts healthy volunteers | No |
| Gender | Both |
| Age group | 18 Years to 75 Years |
| Eligibility |
Inclusion Criteria: Healthy adults (ASA 1-2) for scheduled surgery under general anesthesia with propofol Exclusion Criteria: - pregnant - sedative or analgesic drug 24h before surgery - allergy with drug used in the study - difficulty of communication - absence of informed written consent |
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double-Blind
| Country | Name | City | State |
|---|---|---|---|
| France | Grégoire CHATAIN | Lyon |
| Lead Sponsor | Collaborator |
|---|---|
| Hospices Civils de Lyon |
France,
| Type | Measure | Description | Time frame | Safety issue |
|---|---|---|---|---|
| Primary | After prophylactic solution, evaluation of the pain caused by injection of propofol with a four-point scale before lose of consciousness | |||
| Secondary | Explicite and implicite memory of pain immediately after surgery and on day one | |||
| Secondary | Adverse effects |