Brain and Central Nervous System Tumors Clinical Trial
Official title:
PROTOCOL FOR A PHASE I STUDY OF INTRACYSTIC ANTI-TENASCIN MONOCLONAL ANTIBODY 131I 81C6 IN THE TREATMENT OF PATIENTS WITH RECURRENT CYSTIC GLIOMAS
RATIONALE: Monoclonal antibodies can locate tumor cells and either kill them or deliver
tumor-killing substances to them without harming normal cells.
PURPOSE: Phase I trial to determine the effectiveness of monoclonal antibody in treating
patients with recurrent gliomas.
OBJECTIVES: I. Assess the toxic effects of intracystic administration of iodine-131-labeled
anti-tenascin monoclonal antibody 81C6. II. Identify any objective therapeutic responses to
this treatment in patients with recurrent cystic anaplastic gliomas.
OUTLINE: Radioimmunotherapy. Iodine-131-Labeled Anti-Tenascin Monoclonal Antibody 81C6,
131I-81C6.
PROJECTED ACCRUAL: Three to six patients will be entered at each dose studied.
;
Primary Purpose: Treatment
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