Brain and Central Nervous System Tumors Clinical Trial
Official title:
EFFECT OF DIBROMODULCITOL PLUS BCNU ON FREE INTERVAL AND SURVIVAL OF PATIENTS WITH SUPRATENTORIAL MALIGNANT BRAIN GLIOMAS, A PHASE III TYPE STUDY
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells and may be an
effective treatment for patients with anaplastic astrocytomas.
PURPOSE: Randomized phase III trial to study the effectiveness of radiation therapy in
treating patients with anaplastic astrocytomas.
OBJECTIVES: I. Compare the disease-free interval and survival in patients with
supratentorial malignant brain gliomas randomized to radiotherapy alone vs. radiotherapy
plus radiosensitization with mitolactol (DBD) followed by DBD and carmustine.
OUTLINE: Randomized study. Group I: Radiotherapy. External-beam cranial irradiation with
megavoltage equipment. Group II: Radiotherapy with Radiosensitization followed by
Maintenance Chemotherapy. Radiotherapy as in Group I; with Mitolactol, DBD, NSC-104800;
followed by DBD; Carmustine, BCNU, NSC-409962.
PROJECTED ACCRUAL: A total of 212 patients will be entered over more than 3 years.
;
Allocation: Randomized, Primary Purpose: Treatment
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