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A Study of KC1036 Versus Investigator's Choice of Chemotherapy in Patients With Advanced Esophageal Cancer

Esophageal Squamous Cell Carcinoma Clinical Trial

Official title:
A Randomized, Controlled, Open-label, Multicenter Phase III Study to Evaluate the Efficacy and Safety of KC1036 Versus Investigator's Choice of Chemotherapy as Third-line Therapy in Patients With Advanced Esophageal Squamous Cell Carcinoma

Clinical Trial Summary

The purpose of this study is to evaluate the efficacy and safety of KC1036 versus investigator's choice of chemotherapy in patients with advanced recurrent or metastatic esophageal squamous cell carcinoma

Clinical Trial Description

This is a randomized, controlled, open-label, multicenter phase III trial. Patients with advanced recurrent or metastatic esophageal squamous cell carcinoma that has received PD-1 or PD-L1 inhibitors and at least second-line systemic therapy will be randomized at a 1: 1 ratio to receive KC1036 or the investigator's choice of chemotherapy (Irinotecan/Docetaxel/S-1) until confirmed disease progression assessed by the RECIST V1.1 standard, death, intolerable toxicity, initiation of a new anti-tumor therapy, other reasons leading to treatment discontinuation as specified by protocol. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06194734
Study type Interventional
Source Beijing Konruns Pharmaceutical Co., Ltd.
Contact Jing Huang, Ph.D
Phone 010-87788293
Email huangjingwg@163.com
Status Recruiting
Phase Phase 3
Start date February 5, 2024
Completion date December 30, 2027
View Details
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