Preterm Neonate Analgesia Clinical Trial
Official title:
Efficacy of Melatonin as an Analgesic in Preterm Neonate
Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone secreted by the pineal gland with several important functions, including regulation of the circadian rhythms, and antioxidant and anti-inflammatory effects, accumulating evidence revealed that it also plays an important role in pain modulation through multiple mechanisms. The investigators aimed to evaluate the analgesic effect of melatonin during venous cannula insertion in preterm neonates by assessing Premature Infant pain Profile score (PIPP) before and 5 minutes after the procedure, and to demonstrate the significant relationship between procedural pain and Malondialdehyde (MDA), a well-accepted marker of oxidative stress through measuring MDA after 60 minutes of the procedure.
n/a