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Clinical Trial Summary

The aim is to test the physiological effects of continuous anterior chest compression in patients with severe to moderate ARDS.


Clinical Trial Description

Acute respiratory distress syndrome (ARDS) is usually characterized by inhomogeneous lesions, leading to an inhomogeneous distribution of the mechanical ventilation with the following several deleterious effects: atelectrauma of dependent posterior areas and overdistension in the anterior ones. Therefore, the gold standard treatment is to prevent VILI with lung protective ventilation : low tidal volume, high positive end expiratory pressure and prone positioning which is a technique that reduces mortality. Prone positioning has several beneficial effects : it relieves cardiac compression of the supporting lung, it stiffens the anterior chest wall thus limiting the risk of overdistension of anterior areas and promotes recruitment of non-dependent posterior pulmonary units. The overall effect is a more uniform distribution of transpulmonary pressures and improved ventilation to perfusion ratios. Similar to prone positioning, continuous anterior chest wall compression stiffens the anterior chest wall. The investigators hypothesize that such reduction in anterior chest wall compliance may protect against overdistension and promote the redistribution of the ventilation in posterior areas. ;


Study Design


NCT number NCT05876468
Study type Interventional
Source Assistance Publique - Hôpitaux de Paris
Contact Guillaume CARTEAUX, MD, PhD
Phone (+33) 01 45 17 86 38
Email guillaume.carteaux@aphp.fr
Status Recruiting
Phase N/A
Start date April 1, 2022
Completion date June 28, 2024