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A Multicenter Open-label Clinical Study on the Prevention of Premature Ovarian Failure After HSCT

Hematopoietic Stem Cell Transplantation Clinical Trial

Official title:
A Multicenter Open-label Clinical Study on the Prevention of Premature Ovarian Failure After Hematopoietic Stem Cell Transplantation

Clinical Trial Summary

HSCT is an effective method to cure hematologic malignancies. However, the reproductive system is prone to be damaged during radiotherapy and chemotherapy before transplantation, leading to ovarian failure, followed by infertility and premature ovarian failure (POF), which seriously affect the long-term quality of life of patients. This clinical trial aimed to observe the effect of Gonadotropin-releasing hormone analogues (GnRHa) on ovarian function in women of reproductive age after HSCT, so as to provide clinical evidence for whether GnRHa should be used for the prevention of POF.

Clinical Trial Description

Hematopoietic stem cell transplantation (HSCT) is an effective method for the treatment of hematologic malignancies. However, in the process of radiotherapy and chemotherapy before transplantation, the reproductive system is vulnerable to damage, leading to ovarian failure, which leads to infertility and premature ovarian failure (POF), seriously affecting the long-term quality of life of patients. Exogenous injection of gonadotropin-releasing hormone analogue (GnRHa) has a significant effect on fertility preservation in adolescent and reproductive female patients with breast cancer and cervical cancer. However, there is a lack of large-scale clinical studies on POF in HSCT. Therefore, this clinical trial aimed to observe the effect of GnRHa application before transplantation on ovarian function in women of reproductive age after transplantation, so as to provide clinical evidence for whether GnRHa application for fertility function protection. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05667428
Study type Interventional
Source First Affiliated Hospital Xi'an Jiaotong University
Contact Xiaoning Wang, MD
Phone 0086-18991232608
Email wangxn99@163.com
Status Not yet recruiting
Phase N/A
Start date March 1, 2023
Completion date October 31, 2025
View Details
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