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Clinical Study of TBF Regimen in Allo-HSCT in Patients With CNS Leukemia

Allogeneic Hematopoietic Stem Cell Transplantation Clinical Trial

Official title:
Clinical Study of TBF Regimen in Allogeneic Hematopoietic Stem Cell Transplantation in Patients With Central Nervous System Leukemia

Clinical Trial Summary

Central nervous system (CNS) leukemia is a poor prognostic factor for allogeneic hematopoietic stem cell transplantation (allo-HSCT). Thiotepa can penetrate the blood-brain barrier and has immunosuppressive effects and similar effects to irradiation in allo-HSCT. This project aims to investigate whether the TBF regimen is superior to the traditional modified BuCY2 regimen to improve the long-term survival of the CNS leukemia patients.

Clinical Trial Description

Central nervous system (CNS) leukemia is a common extramedullary leukemia and a poor prognostic factor for allogeneic hematopoietic stem cell transplantation (allo-HSCT). There is a blood-brain barrier (BBB) in the CNS. The treatment effect of CNS leukemia is seriously limited by the low penetration of conventional chemotherapy drugs into cerebrospinal fluid. Thiotepa can penetrate the BBB and has immunosuppressive effect and myeloablative effect similar to irradiation in transplantation. Therefore, it is speculated that cestipide has certain advantages as a conditioning regimen in transplantation for CNS leukemia. This project aims to investigate whether the TBF regimen is superior to the traditional modified BuCY2 regimen to improve the long-term survival of the CNS leukemia patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05667402
Study type Interventional
Source First Affiliated Hospital Xi'an Jiaotong University
Contact Pengcheng He, MD
Phone 0086-85324035
Email hepc@163.com
Status Not yet recruiting
Phase N/A
Start date January 15, 2023
Completion date December 31, 2025
View Details
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