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Monitoring of Cerebral Blood Flow in Patients on Extracorporeal Membrane Oxygenation — NOTICE  

Extracorporeal Membrane Oxygenation Complication Clinical Trial

Official title:
Monitoring of Cerebral Blood Flow in Patients on Extracorporeal Membrane Oxygenation

Clinical Trial Summary

Venovenous extracorporeal membrane oxygenation (VV-ECMO) is a supportive therapy, indicated in case of severe, possibly reversible pulmonary failure, refractory to conventional therapies. Despite advances, morbidity and mortality remain high. Severe neurological complications can occur during ECMO, but their exact etiology is not well understood. It is hypothesized that fast correction of severe hypercapnia, a common indication for venovenous ECMO, may be detrimental for the brain. The supposed mechanism is that fast correction of hypercapnia may result in massive cerebral vasoconstriction and impaired cerebral blood flow (CBF). In this prospective, observational study the aim is to quantify change in CBF during routine initial correction of severe hypercapnia during VV-ECMO. Furthermore, the investigators will record any other hemodynamic changes during VV-ECMO. The hypothesis is that a larger decline in PaCO2 will result in a larger decline of CBF.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05303363
Study type Observational
Source Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Contact Alexander Vlaar, MD PhD MBA
Phone 25846
Email a.p.vlaar@amsterdamumc.nl
Status Recruiting
Phase
Start date December 15, 2021
Completion date August 15, 2025
View Details
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