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A Single and Multiple Dosing Study Targeting Biparatopic Antibody CD38 in Healthy Volunteers

Healthy Volunteer Clinical Trial

Official title:
A Phase 1, Double-blind, Single- and Multiple-ascending Dose Escalation Study of TNB-738, a Biparatopic Antibody Targeting CD38 in Healthy Volunteers

Clinical Trial Summary

This is a Phase 1, Double blind, Single ascending and Multiple ascending dose (SAD and MAD) escalation study in Healthy Volunteers.

Clinical Trial Description

TNB-738 is a fully human bispecific antibody used to inhibit human CD38 enzyme. The study will consist of 2 arms (A and B). The SAD arm (Arm A) of the study consists of sequential single dose escalation cohorts, whereas the MAD portion (Arm B) of the study consists of sequential dose escalation cohorts receiving study drug once every 4 weeks for 3 doses. In both Arm A and Arm B, subjects will be randomized to receive either TNB-738 or matching placebo. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05215912
Study type Interventional
Source Ancora Biotech LLC
Contact
Status Completed
Phase Phase 1
Start date April 21, 2022
Completion date July 11, 2023
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