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Intravitreal Bevacizumab vs Laser vs Combination of Bevacizumab and Modified Laser in PDR

Proliferative Diabetic Retinopathy Clinical Trial

Official title:
Combination Therapy for PDR

Clinical Trial Summary

In this randomized 3-armed clinical trial, 105 eyes with PDR will be included and divided randomly into 3 groups: IVB group (35 eyes) that receive 4 monthly IVB injections and then rescue IVB, PRP group (35 eyes) that undergo full PRP in 2 or 3 sessions and then rescue IVB, and combination group (35 eyes) that receive 2 bimonthly IVB injections and a modified laser (1 session anterior to the equator) and then rescue IVB or laser. Diabetic macular edema (DME) will be treated independently in all groups by IVB. Primary outcome will be the number and activity of neovascularizations at 4,8 and 12 months and secondary measures will be changes in best corrected visual acuity (BCVA) and central macular thickness (CMT), and number of examinations and injection.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04800679
Study type Interventional
Source Shahid Beheshti University of Medical Sciences
Contact Alireza Ramezani, MD
Phone 009822591616
Email labbafi@hotmail.com
Status Recruiting
Phase Phase 2
Start date March 1, 2020
Completion date December 2021
View Details
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