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Timing of Corticosteroids in COVID-19, II. Post COVID-19 Follow-up

Covid19 Clinical Trial

Official title:
Timing of Corticosteroids in COVID-19, II. Post COVID-19 Follow-up

Clinical Trial Summary

Timing of of corticosteroids administration is very important in COVID19 cases for the recovery and decrease the mortality.

Clinical Trial Description

The sickest patients with COVID-19 suffer a hyperinflammatory state-a cytokine storm-that has features in common with a rare haematological condition called haemophagocytic lymphohistiocytosis. Immune suppression should help such patients. By contrast, immune suppression during the early phase of the viral infection might allow increased viral replication and aggravate the disease. The 3C-like proteinase on SARS-CoV-2 (nsp5) inhibits HDAC2 transport into the nucleus, and so impairs the way in which it mediates inflammation and cytokine responses, so activation of histone deacetylase by dexamethasone may directly oppose the action of SARS-CoV-2. Timing of of corticosteroids administration is very important in COVID19 cases for the recovery and decrease the mortality. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04530409
Study type Interventional
Source ClinAmygate
Contact
Status Active, not recruiting
Phase Phase 4
Start date March 20, 2021
Completion date October 15, 2023
View Details
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