QTc Prolongation, Hyperglycemia, Hypoglycemia Clinical Trial
Official title:
Effect of Ciprofloxacin Versus Levofloxacin on QTc-interval and Dysglycemia in Diabetic and Non-Diabetic Patients.
To compare intravenous levofloxacin and ciprofloxacin regarding their risk on the corrected QT interval (QTc) prolongation and dysglycemia in diabetic and non-diabetic patients.
Fluoroquinolones represent an important class of antibacterial drug and they are used
worldwide.Fluoroquinolones are classified into generations according to the spectrum of
antimicrobial activities that targeted them.Fluoroquinolones may cause several side effects
as tendon rupture, central nervous toxicity, cardiovascular toxicity, gastrointestinal
toxicity, phototoxicity, disrupted glucose metabolism, skin disorders and hypersensitivity.
Ciprofloxacin, a second generation fluoroquinolone, is one of the most successful and widely
used compounds of fluoroquinolone. On the other hand, levofloxacin is a third generation
fluoroquinolone.
Diabetes mellitus (DM) is chronic disease and a serious of metabolic disorder associated with
the presence of hyperglycemia due to partial or complete insulin deficiency. Diabetes
mellitus is a major risk factor for cardiovascular diseases.
Fluoroquinolone class is associated with cardiac side effects as QTc prolongation. Some
agents of fluoroquinolones were withdrawn from market. However, cardiac adverse effects has
been developed with fluoroquinolones still in market. Members of fluoroquinolones class have
different effects on QT interval. The US FDA suggested that the risk and benefits ratio of
fluoroquinolones should be taken into consideration.
In addition to hyperglycemia events are more common with fluoroquinolones than with other
classes of antibiotics. The food and drug administration (FDA) confirmed the current warning
that fluoroquinolones may cause decrease in blood sugar especially in diabetic patients.
However, other study proved that fluoroquinolones may cause dysglycemic events in diabetic
and non-diabetic patients.
;