Non-Alcoholic Fatty Liver Disease Clinical Trial
Official title:
Efficacy of Phosphatidylcholine in Addition to Behavior Therapy by Clinical Pharmacist in the Management of Non Alcoholic Fatty Liver (NAFLD)
This study evaluates efficacy of Phosphatidylcholine in addition to life style modification and patient health education by clinical Pharmacist in the Management of Non Alcoholic Fatty Liver NAFLD. All participants with NAFLD will receive life style intervention and half of them will receive additionally Phosphatidylcholine.
As a result of increasing rates of obesity Non Alcoholic Fatty Liver (NAFLD) is the most
common liver disorder affecting 17-46% of adults and parallels the prevalence of Metabolic
Syndrome (MetS) and its components which also increases the risk of more advanced disease
both in adults and in children.
Its pathogenesis is complex and multifactorial, mainly involving genetic, environmental and
metabolic factors. New concepts are constantly appearing in the literature, promising new
diagnostic and therapeutic tools. Further studies are needed to better characterize not only
NAFLD development but overall NAFLD progression, in order to better identify NAFLD patients
at higher risk of metabolic, cardiovascular and neoplastic complications. Pharmacological
treatments aimed primarily at improving liver disease should generally be limited to those
with biopsy-proven Nonalcoholic steatohepatitis (NASH) and liver fibrosis. Not much
therapeutic options for NAFLD are accepted until today besides correction of obesity with
hypocaloric diets and physical exercise and controlling hyperglycemia with diet, insulin, or
oral hypoglycemic agents. Weight loss generally reduces hepatic steatosis.Essential
phospholipid (EPL) as a nutritional supplement is one of the drugs under discussion with
significant positive effects as antioxidative, antifibrotic effects and high biocompatibility
on NAFLD.
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