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Magnesium Replacement and Hyperglycemia After Kidney Transplantation

Kidney Transplantation Clinical Trial

Official title:
Magnesium Replacement and Hyperglycemia After Kidney Transplantation

Clinical Trial Summary

The insulin receptor is dependent on magnesium and hypomagnesemia is associated with increased insulin resistance and decreased insulin secretion and action. Recent data suggest that hypomagnesemia may play a role in development of type 2 diabetes. Kidney transplantation patients have low plasma magnesium levels, partly due to treatment with calcineurin inhibitors. However, the role of magnesium in the development of post-transplant diabetes mellitus (PTDM) is unclear. The present study addresses, whether hypomagnesemia is feasible to reverse by oral administration of magnesium. The investigators wish to investigate whether oral magnesium supplementation is sufficient to increase magnesium levels in kidney transplant recipients, and if supplementation improves glycemic parameters as measured by an oral glucose tolerance test (OGTT).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04382157
Study type Interventional
Source Oslo University Hospital
Contact Rasmus K Carlsen, MD
Phone 004723073544
Email r.k.carlsen@studmed.uio.no
Status Recruiting
Phase Phase 1/Phase 2
Start date February 25, 2020
Completion date August 31, 2022
View Details
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