COVID19 Clinical Trial
Official title:
Assessment of Efficacy and Safety of Tocilizumab Compared to DefeROxamine, Associated With Standards Treatments in COVID-19 (+) Patients Hospitalized In Intensive Care in Tunisia. Multicentric, Comparative, Randomized Study
Assessment of Efficacy and Safety of Tocilizumab Compared to DefeROxamine, associated with
standards treatments in COVID-19 (+) patients, Hospitalized In Intensive care in Tunisia.
Multicentric, comparative, randomized study.
Arm1 :
- Usual standard treatment*
- Tocilizumab (LOC) (8mg/ kg per day) (1 injection per infusion) a second injection may be
considered if necessary, but no more than 800 mg per day. Only on the 1st day (D0)
- Enoxaparin (4000 IU X 2) per day for the duration of hospitalization
VERSUS
Arm 2:
- Usual standard treatment*
- Deferoxamine (Desferal 500 mg, powder, and solvent for IV solution) by electric syringe
40 mg/kg/day 5day/7 without exceeding 5 g per day for 14 days
- Enoxaparin (4000 IU X 2) per day for the duration of hospitalization
Usual standard treatment*: according to the standard practices of each center, apart from the
active molecules of the 2 arms and their therapeutic class)
;
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