COVID Clinical Trial
Official title:
Tear Fluid miRNA Analysis in Sars-Cov2 Conjunctivitis
The aim of this study is to assess the virus RNA, and miRNA levels related to viral
infection, and inflammatory response in tears of hospitalized patients with a diagnosis of
COVID-19 with and without conjunctivitis and to correlate them with clinical condition.
Tears will be collected by using Schirmer Test I, a non invasive painless test which can be
performed at the patient's bed. Tears will be collected on the graduated paper strips pulling
the lower lid gently downward for 5 minutes. Following, the strip will be placed in a 2.0 mL
Eppendorf tube and stored at −80◦C (or - 20°C)
The SARS-CoV-2 is a virus highly infectious whose main target of infection is the respiratory
tract. Virus has been reported to target other mucus tissues, such as the conjunctiva of the
eye and causes conjunctivitis. A recent study has detected the presence of SARS-CoV-2 in the
tears of patients affected by COVID-19 with conjunctivitis, using real-time reverse
transcription polymerase chain reaction (RT-PCR). This suggests that droplets and body fluids
of infected people can contaminate the human conjunctival mucosa and it can be a view of
transmission that it must not be ignored.
A role of miRNAs has been found in ocular infections such as fungal, bacterial, viral
infections. It would be interesting to correlate tear fluid miRNA levels to patients clinical
findings
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