Mechanical Ventilation Complication Clinical Trial
Official title:
Early Identification and Prevention of Extubation Failure in Adults Using Integrated Pulmonary Index: A Randomized Controlled Trial
The primary aim of this study is to compare reintubation rate when using standard medical therapy (SMT) versus a monitoring tool, Integrated Pulmonary Index (IPI), to alert clinicians of the patient's respiratory status and need for therapy after planned extubation.
The study is designed as a randomized controlled trial to compare two methods to guide application of clinical interventions after planned extubation: SMT versus IPI based clinical management among adult patients admitted in the ICU and receiving mechanical ventilation for ≥24 hours. Each mechanically ventilated subject within the inclusion criteria and with a physician order for extubation will be randomized to either the SMT or IPI based clinical management group. Once the extubation order is placed by the medical team, the patient will be randomized to IPI monitoring group or standard medical management group. Patients randomized to IPI group will be placed on IPI monitoring after extubation.Respiratory Therapist (RT) will extubate and connects the patient to EtCO2 cannula (Medtronic, Minneapolis, MN) and will turn on IPI monitoring on the Philips monitor. Any subject with decrease in IPI by 1 within 1 hour of extubation or IPI ≤ 4 after 1 hour of extubation will be assessed by RT and will receive standard medical therapy based on respiratory department protocols. IPI monitoring will be continued for up to 72 hours after extubation. Patients randomized to control group will receive standard medical therapy based on the respiratory department protocols. All patients will be clinically monitored for 72 hours after extubation to assess the extubation outcome. Patients that require reintubation will be reintubated based on the medical team decision and will be discontinued from the study. Patients that do not require reintubation after 72 hours will successfully complete the study. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT05030337 -
Optimising Ventilation in Preterms With Closed-loop Oxygen Control
|
N/A | |
Completed |
NCT05144607 -
Impact of Inspiratory Muscle Pressure Curves on the Ability of Professionals to Identify Patient-ventilator Asynchronies
|
N/A | |
Recruiting |
NCT03697785 -
Weaning Algorithm for Mechanical VEntilation
|
N/A | |
Completed |
NCT05084976 -
Parental Perception of COVID-19 Vaccine in Technology Dependent Patients
|
||
Active, not recruiting |
NCT05886387 -
a Bayesian Analysis of Three Randomised Clinical Trials of Intraoperative Ventilation
|
||
Completed |
NCT04429399 -
Lowering PEEP: Weaning From High PEEP Setting
|
N/A | |
Completed |
NCT02249039 -
Intravenous Clonidine for Sedation in Infants and Children Who Are Mechanically Ventilated - Dosing Finding Study
|
Phase 1 | |
Recruiting |
NCT02071524 -
Evaluation of the Effects of Fluid Therapy on Respiratory Mechanics
|
N/A | |
Completed |
NCT01114022 -
Prevention Inhalation of Bacterial by Using Endotracheal Tube Balloon Polyvinyl Chloride or Polyurethane
|
N/A | |
Completed |
NCT00893763 -
Strategies To Prevent Pneumonia 2 (SToPP2)
|
Phase 2 | |
Terminated |
NCT05056103 -
Automated Secretion Removal in ICU Patients
|
N/A | |
Active, not recruiting |
NCT04558476 -
Efficacy of CONvalescent Plasma in Patients With COVID-19 Treated With Mechanical Ventilation
|
Phase 2 | |
Recruiting |
NCT05295186 -
PAV Trial During SBT Trial
|
||
Active, not recruiting |
NCT05370248 -
The Effect of 6 ml/kg vs 10 ml/kg Tidal Volume on Diaphragm Dysfunction in Critically Mechanically Ventilated Patient
|
N/A | |
Completed |
NCT04589910 -
Measuring Thickness of the Normal Diaphragm in Children Via Ultrasound.
|
N/A | |
Completed |
NCT04818164 -
Prone Position Improves End-Expiratory Lung Volumes in COVID-19 Acute Respiratory Distress Syndrome
|
||
Completed |
NCT04193254 -
LPP , MP and DP:Relation With Mortality and SOFA in Mechanically Ventilated Patients in ER, Ward and ICU
|
||
Completed |
NCT06332768 -
NIV Versus HFO Versus Standard Therapy Immediately After Weaning From Mechanical Ventilation in ARDS Patients
|
N/A | |
Not yet recruiting |
NCT03259854 -
Non Invasive Mechanical Ventilation VERSUS Oxygen MASK
|
N/A | |
Not yet recruiting |
NCT03245684 -
Assisted or Controlled Ventilation in Ards (Ascovent)
|
N/A |