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Super HEROES: Searching How the Extract Rebaudioside Occludes Excess Steatosis

Non-Alcoholic Fatty Liver Disease Clinical Trial

Official title:
Super HEROES: Searching How the Extract Rebaudioside Occludes Excess Steatosis

Clinical Trial Summary

In order to determine whether rebaudioside consumption can be used as a treatment for adolescents with Non-alcoholic Fatty Liver Disease (NAFLD) by demonstrating a decrease in alanine aminotransferase (ALT) levels participants will be randomized to receive one of three 8-week liquid diet interventions: 1. Standard of care 2. Water delivery 3. Water with Rebaudioside (stevia natural sweetener)

Clinical Trial Description

Rationale: Current treatment strategies for Nonalcoholic fatty liver disease, NAFLD, have focused on lifestyle management through a combination of diet and exercise but there are no recommendations for dietary changes that have been proven superior to others. Preliminary data showing an improvement in liver enzymes and fibrosis in mice has demonstrated a novel use of rebaudioside, the non-caloric sweetener (NCS) Stevia leaf's extract, potentially identifying this NCS as a therapeutic intervention where currently there are no targeted treatments. Intervention: All participants will receive standard of care for diet and nutrition. Additionally, participants will be randomized to one of four 8-week liquid diet interventions: 1. Standard of Care 2. Water Delivery 3. Water with Rebaudioside (Stevia Natural Sweetener) Objectives and Purpose: To determine whether rebaudioside consumption can be used as a treatment for adolescents with NAFLD by demonstrating a decrease in ALT levels. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03985020
Study type Interventional
Source Children's Hospital Los Angeles
Contact Asal Gholikhani, BA
Phone 323-361-1432
Email agholikhani@chla.usc.edu
Status Recruiting
Phase N/A
Start date July 26, 2019
Completion date December 31, 2023
View Details
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