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Avelumab + Paclitaxel/ Ramucirumab (RAP) as Second Line Treatment in Gastro-esophageal Adenocarcinoma — AIO-STO-0218  

Gastroesophageal Junction Adenocarcinoma Clinical Trial

Official title:
Avelumab + Paclitaxel/ Ramucirumab as Second Line Treatment in Gastro-esophageal Adenocarcinoma: a Phase II Trial of the AIO (The RAP-Trial)

Clinical Trial Summary

Avelumab + Paclitaxel/ Ramucirumab as second line treatment in gastro-esophageal adenocarcinoma following first-line therapy with platinum and fluoropyrimidine doublet with or without anthracycline, docetaxel or trastuzumab

Clinical Trial Description

Patients with adenocarcinoma of the gastro-esophageal junction or the stomach who have documented progression after being treated with a 1st line chemotherapy which contained at least a platinum and 5-FU (5-Flourouracil)can be included. All patients will receive a standard second line therapy with paclitaxel and ramucirumab plus the investigational drug avelumab, a checkpoint inhibitor. Clinical and radiographic assessment will be performed regularly. Patients will be treated until disease progression, untolerable toxicity or withdrawal of consent. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03966118
Study type Interventional
Source Charite University, Berlin, Germany
Contact Peter Thuss-Patience, MD
Phone +4930450553111
Email peter.thuss@charite.de
Status Recruiting
Phase Phase 2
Start date April 1, 2019
Completion date September 2023
View Details
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