End Stage Renal Disease Clinical Trial
Official title:
Identification of Early Biomarkers of Peritoneal Membrane Dysfunction in Children on Peritoneal Dialysis Using Metabolomics Analysis
Ability and sensitivity of metabolomics analysis to highlight biomarkers or a score of biomarkers that will be able to identify those pediatric patients on peritoneal dialysis at high risk for possible peritoneal dialysis complications and mainly encapsulating peritoneal sclerosis
Ability and sensitivity of metabolomics analysis to highlight biomarkers or a score of
biomarkers that will be able to identify those pediatric patients on peritoneal dialysis at
high risk for possible peritoneal dialysis complications and mainly encapsulating peritoneal
sclerosis. Identification of peritoneal membrane functional status changes over time, at the
same patient (cohort study), by metabolomics, aiming in personalized medicine best practice.
Identification of peritoneal membrane functional status changes over time in immature
infants' peritoneal membrane.
Identification of early and accurate markers of peritoneal membrane dysfunction when membrane
status is possibly reversible that could predict peritoneal patients at risk for future loss
of ultrafiltration and dialysis adequacy of small molecules examined today be PET, KT/V and
Cr/Cl (when membrane status is not reversible).
Improve PD survival in infants and children.
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