Recurrent Urinary Tract Infection Clinical Trial
Official title:
To Investigate and Compare The Efficacy of Urethral Dilatation Versus Glycosaminoglycan Layer Replacement in The Management Of Women With Recurrent Urinary Tract Infections
The aim of this randomised parallel trial is to compare the efficacy of Glycosaminoglycan layer replacement against cystoscopy and urethral dilatation in the treatment of recurrent urinary tract infection in pre-menopausal women. The women will be randomised to 1 of 2 arms.Arm 1 patients will receive standard treatment from the Urologists. This will involve rigid cystoscopy and urethral dilatation, under general anaesthetic. Arm 2 patients will receive standard treatment from the Gynaecologists.
Recurrence of a Urinary Tract Infection (UTI) is defined as infection, following complete resolution of a previous UTI.Recurrent UTI (rUTI) is defined as 3 or more microbiologically confirmed UTI within 12 months. rUTI is an economic problem for healthcare services. rUTI is also detrimental to the quality of life (QoL) of women who suffer the disease. 61% of women who suffer rUTI report symptoms of depression and an associated decrease in their reported QoL scores. QoL was found to improve significantly with successful treatment. E-coli is the most common bacteria causing UTI and 10% are thought to be antibiotic resistant. Consequently, new treatment strategies are required. The Glycosaminoglycans (GAG) layer is thought to be instrumental as a defence mechanism against uro-pathogens. GAG's are polysaccharides forming a gel like substance on the apical surface of the bladder wall and act as a barrier to uro-pathogens. There is now strong evidence that a reduction in the impermeability of the GAG layer is linked to rUTI. Urethral dilatation is an alternative treatment to GAG replacement in the management of rUTI. It is a treatment option more widely adopted by Urologists, although there is a paucity of data to support its use. Currently there is no standardised strategy for the management of women with rUTI. Treatments vary between GAG layer replacement (intravessical therapy with hyaluronic acid and chondroitin sulphate) or a cystoscopy and urethral dilatation. Evidence for each regime varies greatly and is of poor quality. This is a randomised study comparing GAG layer replacement with cystoscopy and urethral dilatation. ;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02357758 -
Effects of Antibiotic Prophylaxis on Recurrent UTI in Children
|
Phase 4 | |
| Completed |
NCT04306731 -
Effect of Nanotechnology Structured Water Magnalife for the Prevention of Recurrent Urinary Tract Infections.
|
N/A | |
| Recruiting |
NCT05553652 -
The Effect of ASTARTE™ on Recurrent Urinary Tract Infection
|
N/A | |
| Completed |
NCT01958073 -
Vaginal Estrogen for the Prevention of Recurrent Urinary Tract Infection in Postmenopausal Women
|
Phase 4 | |
| Recruiting |
NCT05652374 -
Gag Therapy for Recurrent Urinary Tract Infection Assessing Comparability to International Nitrofurantoin Gold Standard Study
|
Phase 4 | |
| Recruiting |
NCT06124820 -
RCT Comparing Intravaginal Laser Therapy to Sham in Post-menopausal Women With Recurrent Urinary Tract Infections
|
N/A | |
| Recruiting |
NCT04807894 -
Prevention of Recurrent UTI Using Vaginal Testosterone Versus Placebo Placebo
|
Phase 4 | |
| Enrolling by invitation |
NCT04077580 -
The Effect of Methenamine Hippurate to Reduce Antibiotic Prescribing in Elderly Women With Recurrent UTI
|
Phase 4 | |
| Terminated |
NCT03143920 -
Hyperbaric Oxygen Therapy for Inflammatory Conditions of the Urinary Bladder
|
Early Phase 1 | |
| Recruiting |
NCT04859621 -
Phase II Clinical Trial of Vitamin D3 for Reducing Recurrence of Recurrent Lower Urinary Tract Infections
|
Phase 2 | |
| Terminated |
NCT04831840 -
Recurrent Urinary Tract Infections and the Microbiome
|
||
| Withdrawn |
NCT03854396 -
Clinical Trial on the Preventive Effect of Intravaginal Prasterone on Recurrent Urinary Tract Infections in Postmenopausal Women
|
Phase 3 | |
| Completed |
NCT02705495 -
Acupuncture for Prevention of Recurrent Urinary Tract Infections.
|
N/A | |
| Active, not recruiting |
NCT05537519 -
Phage Therapy for the Treatment of Urinary Tract Infection
|
Phase 1/Phase 2 | |
| Recruiting |
NCT06035601 -
EHR-integrated rUTI Texting Platform
|
N/A | |
| Not yet recruiting |
NCT04285320 -
Antibiotic Bladder Instillations vs. Oral Suppression for the Treatment of Recurrent Urinary Tract Infections
|
Phase 4 | |
| Recruiting |
NCT03142295 -
Controlled Human Urine Transfusion for UTI
|
N/A | |
| Recruiting |
NCT05895578 -
Effect of a Probiotic on the Urinary Tract Microbiota of Participants With Recurrent Urinary Tract Infection.
|
N/A | |
| Completed |
NCT00214045 -
Rigid Versus Flexible Cystoscopy in Women
|
N/A | |
| Enrolling by invitation |
NCT05551949 -
Preventing Recurrent UTI With Vaginal Estrogen
|
Phase 4 |