Delirium, Cytochrome P-450 Enzyme System Clinical Trial
Official title:
The Impact of Cytochrome P450 Abnormalities in Patients With Delirium. A Pilot Study.
Objectives:
1. To examine whether patients with delirium have higher prevalence of cytochrome-P450
abnormalities compared to patients without delirium.
2. To examine whether the severity of delirium is related to a specific cytochrome P450
genotype.
3. To examine the persistence of delirium at 6-8 weeks stratified by presence of cytochrome
p450 abnormalities
4. To examine whether delirium persistence is impacted by types of medications administered
during their hospital stay.
Delirium is a costly and devastating illness affecting older patients in the hospital. Its prevalence increases as patients get older and sicker. There is scientific evidence that delirium affects cognitive function for a prolonged period of time and in many cases irreversibly. The economic burden on health care and emotional burden on the caregivers of patients with delirium is tremendous. We think that our study may contribute to developing prevention strategies for delirium in the hospital. We propose genetic testing of older patients to determine their ability to metabolize commonly used medications in the hospital. This will give medical professionals and pharmacists an ability to adjust dosages of medications based on the patient's genetic profile. ;