Liver Failure as A Complication of Care Clinical Trial
Official title:
Early Liver Support With MARS in Post-hepatectomy Liver Failure: a Randomized, Multicentre Trial
This is a prospective, randomized, open-label, multicentre study involving European centers with experience in the management of PHLF to assess the impact of early liver support with MARS on survival in patients with post-hepatectomy liver failure (PHLF).
PHLF is a major risk factor for mortality in patients who underwent major hepatectomy. A
specific treatment is yet not available. In a primary proof-of-concept study, it was shown
that it is safe and feasible to use MARS in patients with PHLF early after hepatectomy.
Survival was superior to a historical control group.
This study will include patients with early, primary PHLF (based on the 50:50 criteria) after
major liver surgery. Patients will be randomized 1:1 to receive standard treatment alone or
standard treatment + liver dialysis using the Molecular Adsorbent Recirculating System
(MARS). Relevant outcome along with several physiological parameters will be assessed.
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Withdrawn |
NCT05280990 -
HepaRAS Trial: Changes in Hepatectomy Risk Assessment When Using Mebrofenin HIDA
|
N/A | |
| Recruiting |
NCT04692259 -
May the Risk of PHLF be Predicted With Preoperative Liver Gadoxetate MRI
|
N/A |