Loco-regional Chronic Subdural Hematoma Evacuation Clinical Trial
Official title:
Oral Melatonin as Premedication During Monitored Anaesthesia Care for Patients Undergoing Loco-regional Chronic Subdural Hematoma Evacuation, a Randomized Controlled Trial
investigators assume that administration of preoperative melatonin will reduce the required dose of propofol in participants undergoing loco-regional chronic subdural hematoma evacuation, it may as well provide better postoperative analgesia and decrease the incidence of delirium.
A number of studies showed that premedication with melatonin was associated with sedation
without impairment of cognitive and psychomotor skills or prolonging recovery. Some studies
demonstrated that melatonin decreases the amount of propofol required to produce an adequate
depth of hypnosis at induction time
The effects of the oral administration of melatonin on the dose of propofol sedation in
participants undergoing loco-regional chronic subdural hematoma evacuation have not been
documented before.
The present study will be conducted to detect the efficacy of oral administration of
melatonin on the reduction of the sedative dose of propofol in participants undergoing
loco-regional chronic subdural hematoma evacuation.
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