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Induced Suppression of Platelets Activity in Aneurysmal SAH Management (iSPASM)

Subarachnoid Hemorrhage, Aneurysmal Clinical Trial

Official title:
A Phase 1/2a Exploratory Clinical Trial: Induced Suppression of Platelets Activity in Aneurysmal SAH Management (iSPASM)

Clinical Trial Summary

This is a phase 1/2a, randomized, double blind, single-center study comparing standard care alone to standard care with Aggrastat in patients diagnosed with aneurysmal subarachnoid hemorrhage.

Clinical Trial Description

This is a phase 1/2a, randomized, double blind, single-center study comparing standard care alone to standard care with Aggrastat in patients diagnosed with aneurysmal subarachnoid hemorrhage. The investigational plan is to explore the safety profile of Aggrastat administered continuously over 7 days, beginning at least 12 hours after a clinically indicated Endovascular Coil Embolization procedure. As a part of the study, qualifying subjects will undergo two MRI scans, one at baseline and again prior to discharge. A neurological exam and vital signs will be administered at baseline, daily during drug administration, and at follow-up visits. Additional assessments include administration of the following questionnaires: mRS score, IADL, and QOLIBRI-OS. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03691727
Study type Interventional
Source University of Iowa
Contact
Status Completed
Phase Phase 1/Phase 2
Start date January 24, 2019
Completion date July 1, 2021
View Details
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