Epilepsy Generalized Idiopathic Not Intractable Clinical Trial
Official title:
The Relationship Between Periodic Limb Movement and Seizure Recurrence in Genetic Generalized Epilepsy
The study aimed to study the correlation between periodic limb movement occurring during sleep and the different parameters of genetic generalized epilepsy
Although periodic limb movements are prevalent among patients with epilepsy, the exact
relationship between these movements and epilepsy remains elusive. Objective: The aim of this
work was to study the periodic limb movements among patients with genetic generalized
epilepsy in relation to different clinical characteristics and seizure recurrence. Methods:
Sixty individuals participated in this study: thirty of them were newly diagnosed with
genetic generalized epilepsy and thirty were healthy individuals. Sleep quality was assessed
using the Pittsburgh Sleep Quality Index questionnaire, and a standard polysomnographic study
was conducted to all subjects. All patients then received sodium valproate in therapeutic
doses and were followed up for six months. Electroencephalogram (EEG) was done after the
follow-up period and seizure recurrence was assessed. Accordingly, patients were classified
into three groups according to clinical seizure recurrence and follow-up EEG findings.
Periodic limb movement index and frequency were compared among the patients' groups and were
correlated with different clinical characteristics.
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