Cryoglobulinaemia Due to Chronic Hepatitis C Clinical Trial
Official title:
Different Histopathological Patterns in Patients With HCV Nephropathy
Hepatitis c associated glomerulonephritis is an immune complex disease that occurs in 21% of patients who have HCV infection.
Hepatitis C virus infection is a major public health problem with an estimated global
prevalence of 3% and an estimated 5-20% of infected patients will develop liver cirrhosis
.The Prevalence of Hepatitis C infection in end stage renal disease is greater than in the
general population especially in those on hemodialysis which reflects nosocomial transmission
of the disease in the hemodialysis environment.
Hepatitis C associated glomerulonephritis is an immune complex disease that occurs in 21% of
patients who have HCV infection. It most commonly presents as membranoproliferative and mixed
cryoglobulinemia It characterized by an indolent course in one third of patients , remission
in another third and relapsing course in the remaining patients with potential progression to
advanced chronic kidney disease.
mechanism of injury : Chronic Hepatitis C is primarily associated with type II
cryoglobulinemia , in which the primary mechanism of injury is vasculitis that occurs via
immune complex deposition.
hepatitis C virus related glomerular disease :
Type I membranoproliferative was the most common finding associated with mixed
cryoglobulinemia but other forms of glomerulonephritis were associated with Hepatitis c like
mesangial glomerulonephritis,focal and segmental glomerulonephritis,minimal change
nephropathy,membranous nephropathy , Fibrillary glomerulonephritis,immunotactoid
glomerulopathy,IgA nephropathy, vasculitic renal involvement ,poly arteritis nodosa and
interstitial nephritis .
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