Percutaneous Coronary Intervention Clinical Trial
Official title:
Reassessment of Long-Term Dual Anti-Platelet Therapy Using InDividualized Strategies - Using a Novel Combined Demographic and Pharmacogenomic Strategy: The RAPID EXTEND Pilot Study
In patients with heart attacks, the current standard of care is to restore blood flow through
percutaneous coronary intervention (PCI). This is done using stents (metal meshes) that opens
up blockages. Following PCI, standard preventative drug treatment includes the use of dual
antiplatelet therapy (DAPT) using both aspirin and a platelet P2Y12 receptor inhibitor
(Ticagrelor 90 mg twice a day or Clopidogrel 75 mg once a day) for one year to prevent
clotting that can result in additional heart attacks, sudden clotting of stents or death.
New studies have shown that there is a benefit to continuing DAPT beyond this one year mark.
Longer-term DAPT has been shown to reduce ischemic events (heart attack, stroke) but increase
the risk of bleeding. Present guidelines state that the decision to continue DAPT beyond the
one year mark should be made on an individualized basis.
The present study is a "pilot study" that seeks to compare Long-Term use of Ticagrelor (LTT)
versus a Personalized Approach (PA). We will be recruiting patients who have been stable
(free of ischemic or bleeding outcomes) on DAPT for 1 year after initial presentation with a
heart attack.
The PA group will use a modified DAPT score based on patient demographics to decide whether
treatment is warranted. Patient will also undergo bedside genetic testing to identify
potential at-risk genes. Those identified as carriers will be treated with ticagrelor while
non-carriers will be treated with clopidogrel.
The present study will determine whether a personalized approach will decrease bleeding
versus an approach of universal ticagrelor use.
The hypothesis is that patients receiving a personalized strategy will have a decreased risk
of bleeding.
n/a
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03959072 -
Cardiac Cath Lab Staff Radiation Exposure
|
||
| Not yet recruiting |
NCT05669222 -
The FAVOR V AMI Trial
|
N/A | |
| Recruiting |
NCT04566497 -
Assessment of Adverse Outcome in Asymptomatic Patients With Prior Coronary Revascularization Who Have a Systematic Stress Testing Strategy Or a Non-testing Strategy During Long-term Follow-up.
|
N/A | |
| Recruiting |
NCT05240781 -
Zotarolimus vs Sirolimus Eluting Stent in High Bleeding Risk
|
N/A | |
| Recruiting |
NCT03378934 -
Anti-platelet Effect of Berberine in Patients After Percutaneous Coronary Intervention
|
Phase 4 | |
| Not yet recruiting |
NCT06025071 -
Residual Inflammatory Risk-Guided colcHicine in Elderly Trial
|
Phase 4 | |
| Withdrawn |
NCT04043091 -
Coronary Angiography in Critically Ill Patients With Type II Myocardial Infarction
|
N/A | |
| Completed |
NCT02837744 -
Studying Hemostatic Effect of Axiostat® Dressing on Radial Access After Percutaneous Procedure
|
||
| Completed |
NCT03085823 -
The All-comers Sirolimus-coated Balloon European Registry
|
||
| Completed |
NCT02044146 -
A Pharmacodynamic Study of a Personalized Strategy for P2Y12 Inhibition Versus Ticagrelor in Reducing Ischemic and Bleeding Risk
|
Phase 2/Phase 3 | |
| Completed |
NCT03131271 -
Effect of Ice Bag Application to Femoral Region on Pain in Patients Undergoing Percutaneous Coronary Intervention
|
N/A | |
| Completed |
NCT01156571 -
A Clinical Trial Comparing Cangrelor to Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention (PCI) (CHAMPION PHOENIX)
|
Phase 3 | |
| Completed |
NCT01135667 -
Prasugrel Versus Double Dose Clopidogrel to Treat Clopidogrel Low-responsiveness After PCI
|
Phase 4 | |
| Unknown status |
NCT00751491 -
Clopidogrel Versus Adenosin in Non Urgent Percutaneous Coronary Intervention (PCI)
|
Phase 3 | |
| Completed |
NCT00725868 -
Blood Endothelium Biomarkers to Predict Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention
|
N/A | |
| Completed |
NCT03708588 -
Chewed Versus Integral Pill of Ticagrelor
|
Phase 4 | |
| Completed |
NCT04163393 -
R-One Efficiency For PCI Evolution With Robotic Assistance
|
N/A | |
| Recruiting |
NCT05554588 -
Intrathrombus Thrombolysis Versus Aspiration Thrombectomy During Primary PCI
|
N/A | |
| Recruiting |
NCT06080919 -
Plaque Modification And Impact On Microcirculatory Territory After Drug-Coated Balloon Percutaneous Coronary Intervention (PLAMI).
|
N/A | |
| Recruiting |
NCT05353140 -
LAAO Versus NOAC in Patients With AF and PCI
|
N/A |