Hyperemesis; Gravidarum, With Dehydration Clinical Trial
Official title:
Endothelial Dysfunction in Hyperemesis Gravidarum
The purpose of the study is to determine serum inflammatory adhesion molecules levels in hyperemesis gravidarum
The study population consisted of 2 groups; (1) the hyperemesis gravidarum group, consist of
25 pregnant women who developed dehydration due to HG between 6 and 13 gestational weeks and
between 18 and 35 years (2) the normal pregnancy group, consisting of 25 pregnant women.
HG was defined according to the fallowing American College of Obstetricians and
Gynecologists (ACOG) criteria; severe nausea and vomiting resulted in 5% weight loss with
regard to pre-gestation or vomiting more than 3 times and 3-5 % weight loss with ketonuria.
The diagnosis of dehydration was clinically defined and patients with moderate and severe
dehydration were included in the study. As clinical findings; Weight loss, capillary recall
time, dry mucous membranes, dry eye, pulse rate, systolic blood pressure, respiration, skin
turgor deterioration and urine output were evaluated.
Other pathologies causing nausea and vomiting like; gastroenteritis, gastroparesis, gall
duct diseases, hepatitis, peptic ulcers, appendicitis, pyelonephritis, ovarian torsion,
urinary tract stones, diabetic ketoacidosis, hyperthyroidism, hyperparathyroidism, migraine,
pseudo tumor cerebra, vestibular diseases were excluded from the study.Patients were
excluded from the study in the presence of pregestational diabetes chronic hypertension,
chronic liver and renal failure, preeclampsia history, multiple pregnancy, hyperlipidemia,
hypercholesterolemia, obesity, tobacco use, NSAID drug use, infection within the last three
months and surgery within the last month that could cause endothelial dysfunction.
Blood and urine specimens were collected from the patients with HG during hospitalization
and during regular clinic visits in control group. The 2mL of blood samples were withdrawn
into serum-separating tubes for the measurements of serum biochemical parameters and 2 mL
blood samples were withdrawn into EDTA containing tubes for measurement serum hemoglobin and
hematocrit levels. Early-morning urine samples were collected from study population. These
blood and urine samples were analyzed in same day for Kayseri Education and Research
hospital biochemical clinics. In addition 2mL of blood samples were withdrawn into
serum-separating tubes for analyzing serum sVEGFR-1, sVCAM-1, sE-selectin and sICAM-1
levels. All of the serum were stored at -80°C in nonadsorbable tubes. After three months for
stored first blood sample, serum sVEGFR-1, sVCAM-1, sE-selectin and sICAM-1 levels were
determined by an enzyme linked immunosorbent assay.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02963753 -
Hyperemesis Gravidarum and 75 Gram Oral Glucose Tolerance Test
|
N/A |