Shockable Out of Hospital Cardiac Arrest Clinical Trial
Official title:
CYclosporine A in Shockable Out-of-hospital Cardiac Arrest ResUScitation
Cardiac arrest (CA) is a public health problem in industrialized countries. The prognosis of
these patients remains poor with significant mortality and severe neurological sequelae in
survivors.
The objective of the present study is to determine whether cyclosporine can improve patient
clinical outcome after shockable CA. 520 patients with CA will be entered into a multicentre,
randomized, placebo-controlled study. They will receive one single injection of cyclosporine
(or placebo) prior to resuscitation. The incidence of the combined endpoint (mortality,
irreversible brain damage informations such as bilateral abolition of N20 wave or absent
motor response or extension to the nociceptive stimulation…) will be assessed 7 days after
CA.
n/a