Acute Endophthalmitis Post-operative Clinical Trial
Official title:
Contribution of Fast Molecular Bacterial Identification by Real-time PCR in Managing of Postoperative Acute Endophthalmitis
Endophthalmitis is a serious eye infection of exogenous origin (post-operational,
post-traumatic) or endogenous origin (metastatic). This is a diagnostic and therapeutic
emergency.
Each patient suffering from endophthalmitis must have immediately an ocular sampling, an
intra ocular injection of antibiotics and a systemic antibiotic cover.
The etiological treatment will be adapted according to the infectious agent.
The main goal of this prospective multi-centre trial is to improve the sensitivity and
rapidity of the infectious agent's identification involved in endophthalmitis cases,
particularly virulent species (like Staphylococcus aureus, Streptococcus pneumoniae...) from
ocular samples with the help of real-time PCR.
This will help the ophthalmologist to be more efficient in accordance with the kind of the
bacteria.
Data will also enable to compare both PCR techniques used in this study. The secondary goal
of the prospective study is to characterize the resistance of bacterial's species found
during acute endophthalmitis with the antibiogram and by the study of resistance genes, to
enable to correlate the resistance in vitro with the therapeutic response in vivo and get
precious epidemiological data to adapt prophylactic antibiotic.
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Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Diagnostic