Nutrition Therapy for Critical Illness Clinical Trial
1. Demographics data;
2. Nutritional evaluation data;
3. All biochemical monitoring data during the study period;
4. All nutritional treatment data will be recorded daily during the study period,
including actual calorie intake, protein intake, and the proportion of calorie/protein
administered by EN and/or PN route. The nutritional treatment protocol will be decided
by the attending physician, the investigator will not intervene.
5. A blood sample (5 ml) will be drawn from every patient immediately after they enroll
into the study, and the metabolomics of the samples will be analyzed analysis using a
combined 800 MHz 1H-NMR-UPLC-MS system. The data will then be used to establish
metabolic profile baseline.
6. We will establish a sub-group that contains 20 patients (chosen from enrolled patients
according to APACHE II scores: 10 patients are APACHE II scores in 21-30). We will take
one blood sample daily during the whole study period. The plasma sample will be used
for metabolomics analysis using an 800 MHz 1H-NMR-UPLC-MS system. And the data will be
used for metabolic dynamic modeling.
7. Clinical outcomes data, which include: 1) Complications after the operation (intestinal
fistula, pancreatic fistula, biliary fistula and sepsis, bleeding, nosocomial
infection); 2) death event; 3) ICU-stay; 4) Length of hospitalization
n/a
Observational Model: Cohort, Time Perspective: Prospective