State Key Laboratory of Respiratory Disease Clinical Trial
Official title:
Study of Neural Inspiratory Time and Expiratory Delay in Patients and Healthy Subjects During Unassisted Spontaneous Breathing and Mechanical Ventilation.
To make these definitions of neural inspiratory time (Ti) and expiratory delay clearly.The present study was undertaken to examined the physiological signals of patients and healthy subjects during spontaneous breathing and noninvasive mechanical ventilation.
In total, 8 chronic obstructive pulmonary disease (COPD) patients, 8 patients with
interstitial lung disease (ILD) and 8 healthy subjects were recruited.
The patient was studied at the afternoon in a semirecumbent position. After the application
of topical anaesthesia (2% xylocaine), the patient was asked to swallow two balloon-tipped
catheters and the multi-pair esophageal electrode catheter through the nose into the their
right position.
At the first period, the stable signals of unassisted spontaneous breathing (about 5min)
were chosen to be recorded. After this period, the patient was placed on noninvasive
pressure support ventilation(PSV). The inspiratory positive airway pressure (IPAP) was
initially titrated by patient's tolerance . The noninvasive ventilation lasted at least 20
minutes until the breathing was stable. All the raw signals were recorded. The last 15
minutes of the stable computer-stored data were calculated and analyzed. The leaks were
monitored by the display of the ventilator and the computer during the procedure. When the
leak was observed, the mask was carefully adjusted to prevent. Esophageal and gastric
balloon－catheters were used to detect the intra-thoracic and abdominal pressure. Airway
pressure was also measured simultaneously. EMGdi was recorded from a multipair esophageal
electrode .During ventilation Airflow and ventilation were measured with pneumotachograph.
Respiratory rate, tidal volume,the time difference between the initial increase and the
termination of the diaphragm electromyogram(EMGdi) , time difference between maximal value
of EMGdi and the end of inspiratory flow,time difference between the point of zero flow
between inspiration and expiration ,and the time difference between the onset of the upward
deflection in transdiagramic pressure( Pdi) and the return of Pdi were calculated during the
unassisted spontaneous breathing and mechanical ventilation.
;
Intervention Model: Single Group Assignment, Masking: Open Label
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02877121 -
Respiratory Muscle Function and Neural Respiratory Drive in Interstitial Lung Disease
|
N/A |