Liver Transplantation Clinical Trial
Official title:
Postoperative Renal, Pulmonary, Cardiovascular Complications and Use of Blood Components in Patients Undergoing Liver Transplantation
Incidence and risk factors for renal, cardiovascular and pulmonary complications after liver
transplantation are not well defined. Blood products requirement is an important aspect of
orthotropic liver transplantation (OLTx) management and has a great impact on patient's
outcome. Transfusions of blood products increase perioperative complications and reduce graft
and patients survival.
The primary endpoint of the study is to evaluate the incidence of renal complication during
ICU stay after liver transplantation using RIFLE criteria; secondary endpoint is to evaluate
the incidence of cardiovascular and pulmonary complications. In addition patients' survival
and the relationship between blood components use with the development of post-operative
complications are evaluated.
It is conducted a prospective observational cohort study in all Italian liver transplant
centers. Adult (> 18 years old) recipients of deceased liver graft between January 2011 and
December 2013 were eligible for inclusion. Exclusion criteria were the use of living organ
donation, retransplantation, pediatric transplantations, combined transplantation and
fulminant hepatic failure.
Investigators collected data using a prospectively maintained computer database managed by
the Italian Ministry of Health "Centro Nazionale Trapianti". Anesthetic and perioperative
management followed the routine local institution protocols.
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|---|---|---|---|
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