Propofol Pharmacokinetics and Pharmacodynamics Modelling

Intravenous Anesthetic Agent Overdose Clinical Trial

Official title:
Modelling Propofol Pharmacokinetics and Pharmacodynamics During an Intravenous Anaesthesia Guided by the Bispectral Index (BIS)

Status Completed

Clinical Trial Summary

The main purpose of this research is to develop a population pharmacokinetic and pharmacodynamic model of Propofol when used for induction and maintenance of anaesthesia, using BIS as a pharmacodynamic endpoint.

A covariate analysis will be performed in order to account for variability in pharmacokinetic and pharmacodynamic parameters. The influence of age and obesity on propofol pharmacokinetic parameters will be particularly addressed.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Intravenous Anesthetic Agent Overdose

Clinical Trial Details

NCT number	NCT02713698
Study type	Observational
Source	Centro Hospitalar do Porto
Contact
Status	Completed
Phase
Start date	April 1, 2016
Completion date	April 28, 2017

View Details

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