Efficacy and Safety of Non-invasive Ventilation by Calibrated Leak in the Treatment of Respiratory Acidosis in ICU — VNI Versus  

Respiratory Acidosis in ICU Patients Clinical Trial

Status Terminated

Clinical Trial Summary

VNI Versus is a clinical, prospective, randomized, cross over study, aiming to compare two mechanical ventilators during non-invasive ventilation for patient suffering from respiratory acidosis.

This study will compare a dedicated ventilator for Non Invasive Ventilation (NIV) functioning with a turbine and with vented mask (exhalation by a calibrated leak) and a dedicated ventilator for Intensive Care Unit (ICU), functioning with non-vented masks and an exhalation valve.

Patient will be randomized before the first NIV session lasting 2 hours. After a two hours wash-out, a second NIV treatment will be delivered with the other ventilator for duration of 2 hours.

Arterial blood samples will be collected at the beginning and the end of each session of NIV. A transcutaneous captor of dioxide carbon pressure (PCO2) will also be used for patient monitoring.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Acidosis
• Respiratory Acidosis in ICU Patients

• NCT number: NCT02630784
• Study type: Interventional
• Source: University Hospital, Grenoble
• Status: Terminated
• Phase: N/A
• Start date: May 27, 2015
• Completion date: May 5, 2018