Obstructive Sleep Apnoea Syndrome Clinical Trial
Official title:
Dietary Nitrate for OSAS: a Randomized, Placebo-controlled, Crossover Trial.
Acute consumption of dietary nitrate (as beetroot juice) has been shown to decrease systemic blood pressure in multiple populations as well as increase organ perfusion in areas of interest such as the pancreas and brain. Obstructive sleep apnoea syndrome (OSAS) is associated with high blood pressure, dysglycaemia and impaired vigilance. The effect of dietary nitrate in OSAS has not been reported.
Acute consumption of dietary nitrate (as beetroot juice) has been shown to decrease systemic
blood pressure in multiple populations as well as increase organ perfusion in areas of
interest such as the pancreas and brain. Obstructive sleep apnoea syndrome (OSAS) is
associated with high blood pressure, dysglycaemia and impaired vigilance. The effect of
dietary nitrate in OSAS has not been reported.
The investigators hypothesize that chronic nitrate consumption might decrease blood pressure
and dysglycaemia and improve vigilance compared to a placebo beetroot juice.
This study is a randomized, double-blind placebo-controlled, crossover trial. At baseline,
mid-point and endpoint ambulatory blood pressure will be assessed in conjunction with
demographics, questionnaires, vigilance and blood draw. After baseline measures, each
subject will be randomized to consume nitrate rich beetroot juice for 14 consecutive nights
when assessments will be repeated followed by 14 nights of placebo and endpoint assessments
or the converse.
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator, Outcomes Assessor), Primary Purpose: Supportive Care
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