Kidney Transplant Recipients Clinical Trial
Official title:
Circulating Donor-Derived Cell-free DNA in Blood for Diagnosing Acute Rejection in Kidney Transplant Recipients
This is a prospective, multicenter, observational study of kidney transplant subjects where blood specimens, intended for dd-cfDNA and other future research purposes, will be drawn after transplant
This is a prospective, multicenter, observational study of kidney transplant subjects where
blood specimens, intended for dd-cfDNA and other future research purposes, will be drawn
after transplant periodically and also after the treatment of acute rejection up to 8 weeks
post treatment. The blood samples and all relevant clinical data will be provided to CareDx
scientists for laboratory assay of dd-cfDNA levels and correlation of dd-cfDNA levels with
the clinical features of the subjects.
The primary objective of the study is to correlate circulating dd-cfDNA to clinical and
sub-clinical acute rejection in renal allograft recipients. The secondary objective of the
study is to correlate circulating dd-cfDNA to renal function, both serum creatinine and
estimated glomerular filtration rate [eGFR]).
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