Chronic Graft Versus Host Disease Clinical Trial
Official title:
EVALUATION OF THE DIAGNOSTIC VALUE OF PET (18F-FDG) IN CHRONIC GRAFT VERSUS HOST DISEASE (cGVH)
Allogeneic stem cell transplantation was developed to cure many patients with hematological
malignancies. It results in the development of graft versus host disease (GVHD) in 30-70% of
cases. Chronic GVHD diagnosis currently uses biopsies of affected organs (skin, liver,
gastrointestinal tract) and / or the observation of typical clinical signs sufficient for
diagnosis. However, the anatomical sites for biopsy including the digestive tract are not
clearly identified (high or low biopsy) and may present risks in their realization in
particular in patients weakened by blood disease or immunosuppression.
PET-CT with 18F-FDG has already been evaluated in chronic inflammatory diseases such as
Crohns disease with good sensitivity and specificity. It interest in the graft against the
host was studied in acute forms of digestive and allows lesion mapping and monitoring the
effectiveness of treatment.
Among patients with chronic GVHD scleroderma form, PET with 18F-FDG enabled to view
musculoskeletal uptakes localized to the affected areas identified with MRI.
The investigators propose a study evaluating the sensitivity and specificity of the
examination by PET-CT with 18F-FDG in the diagnosis of chronic GVHD compared to conventional
diagnostic tools.
Patients will have PET/CT at day 150+/-15d post-hematopoietic stem cell transplantation (HSCT) ;
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