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Involvement of Steatosis-induced Glucagon Resistance in Hyperglucagonaemia

Non-alcoholic Fatty Liver Disease Clinical Trial

Official title:
Involvement of Steatosis-induced Glucagon Resistance in Hyperglucagonaemia

Clinical Trial Summary

The purpose of this study is to examine whether non-alcoholic fatty liver disease (NAFLD) is associated with hepatic glucagon resistance and hyperglucagonemia.

Clinical Trial Description

Hyperglucagonemia is a common condition in obesity, prediabetes and type 2 diabetes. It increases the hepatic glucose production, thus contributing to type 2-diabetic hyperglycemia. In the current study we wish to examine whether non-alcoholic fatty disease (NAFLD) results in hepatic glucagon resistance. This could result in hyperglucagonemia through a feedback mechanism acting on the level of pancreatic alpha cells. Cirrhosis and type 1 diabetes, respectively, has previously been shown to be associated with hepatic glucagon resistance but it has not been examined in relation to NAFLD in humans so far. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02337660
Study type Interventional
Source University Hospital, Gentofte, Copenhagen
Contact
Status Completed
Phase N/A
Start date January 2015
Completion date January 2016
View Details
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