Unspecified Adult Solid Tumor, Protocol Specific Clinical Trial
Official title:
Prediction of Response of Brain Metastases to Brain Irradiation Using Voxel Based Diffusion Tensor Imaging
This pilot clinical trial studies how well voxel based diffusion tensor imaging in predicting response in patients with brain metastases undergoing whole-brain radiation therapy or stereotactic radiosurgery. Voxel based diffusion tensor imaging (VB-DTI) may allow doctors to measure response to whole brain radiation therapy or stereotactic radiosurgery earlier than is possible with a standard magnetic resonance imaging. The earlier ability to measure response may allow for consideration of alternative therapies at an earlier stage.
PRIMARY OBJECTIVES:
I. To determine if voxel based diffusion tensor imaging will provide an early predictive
assessment of therapy response, as compared to radiographic volumetric response criteria.
OUTLINE:
Patients undergoing whole-brain radiation therapy (WBRT) for a total of 10 fractions also
undergo VB-DTI magnetic resonance imaging (MRI) at baseline, 1 week after WBRT initiation,
and 7-11 days after completion of WBRT. Patients undergoing stereotactic radiosurgery (SRS)
without WBRT also undergo VB-DTI MRI at baseline and 7-11 days after completion of SRS.
After completion of study, patients are followed up every 2 months for 6 months and then
every 6 months until death.
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