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Effect of Ranolazine on Gastrointestinal Motor Function and Pain in Patients With IBS-D — Ranolazine  

Diarrhea Predominant Irritable Bowel Syndrome Clinical Trial

Official title:
Effect of Ranolazine on Gastrointestinal Motor Function and Pain in Patients With Diarrhea-predominant Irritable Bowel Syndrome (IBS-D)

Clinical Trial Summary

Will Ranolazine improve bowel function and abdominal pain in human subjects with IBS-D?

Clinical Trial Description

This is a randomized double-blind placebo-controlled pilot study that will use validated bowel questionnaires to evaluate the effects of ranolazine administered orally twice daily in patients with diarrhea predominant IBS (IBS-D). The study will consist of a 2 week run in period, followed by 4 weeks of treatment period with oral ranolazine 1000 mg twice daily. Primary endpoint of the study will be the average Bowel Symptom Scale (BSS) scores for diarrhea and adequate relief of IBS pain and discomfort are secondary end points. ;

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02239926
Study type Interventional
Source Mayo Clinic
Contact
Status Terminated
Phase Phase 2/Phase 3
Start date September 2014
Completion date September 2015
View Details
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