Patient With Influenza Like Illness Clinical Trial
Official title:
Influenza Vaccination of HCW and Hospital Acquired Influenza in Patients
Hospital acquired influenza is associated with significant morbidity and mortality in
hospitalized patients notably elderly patients. Vaccination of HCW is recommended to prevent
influenza transmission in healthcare setting.
Outbreaks of hospital acquired influenza were reported in stays with high vaccine coverage
in patients (higher than 85%). It is necessary to underline that an adequate vaccine cover
in the elderly population will not necessarily result in a total control of the incidence.
Consequently, the prevention of influenza outbreaks in this vulnerable population must also
include the reduction of the exposure to the influenza viruses, in particular thanks to the
vaccination of HCW.
A pilote case-control study, implemented in Edouard Herriot hospital (at Lyon University
hospitals), indicates that a shielding effect of more than 35% of vaccinated HCW on hospital
acquired influenza among patients (Bénet et al.; BMC Infectious Diseases 2012). The results
suggest a protective effect but investigations, carried out on a more important sample are
needed to validate the benefit of HCW vaccination.
The aim of this prospective multicentric cohort study is to estimate incidence of influenza
among hospitalized patients according to % of influenza vaccination of HCW in short stay
units.
n/a
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention