Chronic Progressive External Ophthalmoplegia Clinical Trial
Official title:
Magnetic Resonance Imaging Study of Patients With Chronic Progressive External Ophthalmoplegia
The purpose of this study is to investigate the fraction of fat on a MRI scan of lower bag
muscles, thighs and calves in patients with the mitochondrial disease chronic progressive
external ophthalmoplegia (CPEO).
Additionally an investigation of the volume of the eye muscles will be done and compared to
the patient's clinical presentation of ptosis and ophthalmoplegia.
The lack of energy and fatigue seen in patients with mitochondrial diseases have been
assumed to be caused by an energy defect because of a genetic defect in the mitochondrial
DNA.
The investigators have analyzed a few MRI scans of muscles from patients with CPEO and have
seen an extended amount of fat in their muscles, which seems to progress with age. The
patient's symptoms might be caused by the extended amount of fat and thereby a less amount
of active muscle instead of the "energy defect".
This will be investigated in a group of patients with CPEO and the results will be compared
with results from a group of healthy controls.
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Time Perspective: Cross-Sectional
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Active, not recruiting |
NCT04678115 -
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|
N/A |