Clinical Trials Logo

Clinical Trial Summary

EuRhythDia II is a multicenter, randomized, double-blind controlled study. The rationale of EuRhythdia is to explore the effects of 12 weeks of timed melatonin treatment on circadian rhythm, metabolic control and cardiovascular function in night shift workers. The 12 weeks of intervention will be followed by 12 weeks of washing out.


Clinical Trial Description

Modern lifestyle has dramatically changed the daily rhythms of life. Physical activity, diet and light exposure are no longer restricted to daytime hours due to increased shift work. Recent scientific reports have shown that shift work leads to disruption of circadian rhythms and promotes diabetes, obesity and cardiovascular disease. Until now only few studies investigating circadian rhythm disturbances in the context of type 2 diabetes and obesity have been conducted in man. Thus, knowledge of the molecular pathways and the responsibles genes in man are missing and have been identified only in animal studies.

The objective of the project is to achieve breakthroughs in the understanding of the causality between inner clock rhythm disturbances and the development of type 2 diabetes and obesity. The provided data on the interaction between genes, epigenetics, metabolism, cardiovascular function and the internal clock are intended to contribute to identify novel biomarkers and novel therapeutic approaches focusing on circadian rhythms to reduce the occurence of diabetes and obesity in shift worker. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT02108353
Study type Interventional
Source Universitätsklinikum Hamburg-Eppendorf
Contact
Status Completed
Phase Phase 3
Start date January 2015
Completion date March 29, 2017

See also
  Status Clinical Trial Phase
Completed NCT05346588 - THRIVE Feasibility Trial Phase 3
Recruiting NCT05991453 - Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial N/A
Withdrawn NCT05096130 - Lifestyle Medicine Strategies for Combating Sleepiness and Fatigue in Professional Drivers N/A
Completed NCT01327040 - Light Sensitization Study N/A
Completed NCT00593736 - Efficacy of Ramelteon on Speeding Up Sleep in Subjects With Delayed Sleep Phase Syndrome Phase 2
Recruiting NCT00387179 - Effectiveness of Combining Light and Non-Light Treatments for Jet Lag and Sleep Disorders N/A
Recruiting NCT04900675 - Bright Light Intervention to Reduce Students' Stress N/A
Completed NCT01881854 - Sleep Wake and Melatonin Pattern in Craniopharyngioma N/A
Completed NCT00246051 - Comprehensive Police Fatigue Management Program N/A
Recruiting NCT04690504 - Validation of Circadian Biomarkers in Patients With Sleep Disorders
Completed NCT03363529 - ROOM-LIGHT: Dynamic LED-light as Treatment for Depressed Patients in Inpatient Wards N/A
Recruiting NCT05701969 - Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift Early Phase 1
Completed NCT00723580 - Actigraphic Analysis of Treatment Response N/A
Completed NCT00207285 - Sleep Disorders Management, Health and Safety in Police N/A
Not yet recruiting NCT06336525 - Adult Sleep Health in the Rural Appalachia and Mississippi Delta Region and Its Relationships With Cardiometabolic Health Disparities.
Recruiting NCT05618405 - Changes in Circadian Rhythm After Anaesthesia in Children
Completed NCT05684523 - Feasibility Study on the Use of Redormin®500 on Day-time Cognition Phase 4
Recruiting NCT05247125 - The Role of Circadian Factors in Regulation of Neuroplasticity in Ischemic Stroke (Interventional) Phase 4
Completed NCT04219566 - Vestibular Nerve Stimulation to Improve Sleep N/A
Not yet recruiting NCT06181110 - Sleep-Wake Patterns on Illness Trajectories and Treatment Response in MDD N/A