End-stage Renal Disease Clinical Trial
Official title:
Effectiveness of High-volume Online Hemodiafiltration Compared to Standard Volume Online Hemodiafiltration. A Prospective, Multicenter, Randomized, Open-labelled Interventional Study.
Online hemodiafiltration (HDF) may improve clinical outcome in end-stage renal disease. The
supported mechanism is the improved clearance of uremic toxins by convective transporter.
However, It has not been elucidated which convection volume is optimal, especially in Asia.
A total of 60 participants receiving conventional hemodialysis will be randomly assigned to
receive either high dose convective volume (33-43 L/treatment) post-dilution online HDF or
standard dose (16.8-21.5 L/treatment) for 24 weeks. The primary outcome is the change of
serum β2 microglobulin levels between baseline and after 24 weeks. The secondary outcomes
will include changes in the nutritional markers, inflammatory markers, and blood pressure
from baseline to after treatment.
This would be the first multicenter prospective, randomized controlled trial to determine
whether large convective volume improves the treatment efficacy in Korean patients
undergoing post-dilution online HDF.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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