Liver Transplantation Clinical Trial
Official title:
Safety and Feasibility of Multipotent Adult Progenitor Cells for Immunomodulation Therapy After Liver Transplantation: A Phase I Study of the MiSOT Study Consortium
MultiStem ® is a new biological product, manufactured from human stem cells obtained from
adult bone marrow. Factors expressed by MultiStem cells are believed to regulate immune
system function and augment tissue repair.
Standard of care pharmacological immunosuppression after liver transplantation can achieve
reasonable survival of liver grafts and patients. The side effects of this treatment,
however, are clinically significant and diminish the overall success of organ transplantation
as a curative therapy. It is therefore the objective of this study to implement cellular
immunomodulation therapy with MultiStem as an adjunct to standard pharmacological
immunosuppression with the ultimate goal of significantly reducing drug-based
immunosuppression.
As this is the first study with MultiStem in this subject population it has been designed as
a safety and feasibility trial. However, first evidence of a potential benefit for this
patient population will be explored cautiously.
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