Stage I Testicular Non-Seminomatous Germ Cell Tumor Clinical Trial
Official title:
A Single Group Trial Evaluating One Cycle of Adjuvant BEP Chemotherapy in High Risk, Stage 1 Non-seminomatous Germ Cell Tumours of the Testis (NSGCTT)
High-risk stage 1 NSGCTTs are curable with careful surveillance followed by 3 cycles of BEP
(bleomycin, etoposide, cisplatin with 500mg/m2 of etoposide per cycle) chemotherapy for the
40-50% of cases experiencing recurrence. Alternatively, adjuvant chemotherapy with 2 cycles
of BEP(at a lower dose than that used for advanced disease - etoposide 360mg/m2) for these
patients achieves the same outcome and avoids intensive surveillance, but delivers 33% more
chemotherapy cycles on a population basis.
If a single cycle of BEP at the dose used in advanced disease had a similar high rate of
relapse-free survival (cure) to that seen with two lower dose cycles, this would reduce the
overall burden of chemotherapy and healthcare resource usage and would be likely to lead to a
change in practice globally.
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