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Trial Evaluating PCSK9 Antibody in Subjects With LDL Receptor Abnormalities — TESLA  

Homozygous Familial Hypercholesterolemia Clinical Trial

Official title:
2-part, Phase 2/3 Study to Assess the Safety, Tolerability and Efficacy of AMG 145 in Subjects With Homozygous Familial Hypercholesterolemia. Part A - Open-label, Single-arm, Multicenter Pilot Study to Evaluate Safety, Tolerability and Efficacy of AMG 145 in Subjects With Homozygous Familial Hypercholesterolemia. Part B - Double-blind, Randomized, Placebo-controlled, Multicenter Study to Evaluate Safety, Tolerability and Efficacy of AMG 145 in Subjects With Homozygous Familial Hypercholesterolemia

Clinical Trial Summary

A study to determine the safety, tolerability, and efficacy of evolocumab (AMG 145) in patients with homozygous familial hypercholesterolemia (HoFH).

Clinical Trial Description

Study Masking:

Part A: Open Label Part B: Double Blind ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01588496
Study type Interventional
Source Amgen
Contact
Status Completed
Phase Phase 2/Phase 3
Start date April 5, 2012
Completion date January 31, 2014
View Details
See also
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